Genetically predicted RNA phenotypes

cis-genetic associations can be used to predict quantitative RNA phenotypes such as gene expression levels and isoform ratios. These values estimate z-scores of the phenotypes, rather than absolute levels, but can be used to:

Stratify individuals by a gene's genetically predicted expression or other RNA phenotype to test hypotheses about the gene's role in observed traits. See Campo et al. 2025 (preprint)
Test whether observed gene expression differences in groups with divergent traits are only a downstream effect of exposures or whether they have a more direct genetic component. See Zhou et al. 2023

We provide predictions for 124,502 unique RNA phenotypes for 19,885 genes for all rats genotyped by our NIDA center (Round 11.2, N=24,722). These include only phenotypes that are heritable (P<0.01) in the indicated tissue.